Table VI.
Comparison of adverse events between elderly (≥70 years) and non-elderly (<70 years) patients.
| Adverse events | Total, no. (%)(n=136) | Elderly, no. (%)(n=46) | Non-elderly, no. (%)(n=90) | P-value |
|---|---|---|---|---|
| Leukopenia | ||||
| Grade ≥3 | 37 (22.1) | 15 (32.6) | 22 (24.4) | 0.31 |
| Grade ≥4 | 8 (5.9) | 8 (17.4) | 0 (0.0) | 0.001 |
| Neutropenia | ||||
| Grade ≥3 | 78 (57.3) | 31 (67.4) | 47 (52.2) | 0.091 |
| Grade ≥4 | 27 (19.9) | 14 (30.4) | 13 (14.4) | 0.027 |
| Thrombocytopenia | ||||
| Grade ≥3 | 28 (20.6) | 12 (26.1) | 16 (17.8) | 0.26 |
| Grade ≥4 | 11 (8.1) | 7 (15.2) | 4 (4.4) | 0.035 |
| Anemia | ||||
| Grade ≥3 | 20 (14.7) | 8 (17.4) | 12 (13.3) | 0.53 |
| Grade ≥4 | 1 (0.7) | 1 (2.2) | 0 (0.0) | 0.34 |
| Hematological toxicities | ||||
| Grade ≥3 | 83 (61.0) | 33 (71.7) | 50 (55.6) | 0.057 |
| Grade ≥4 | 28 (20.6) | 15 (32.6) | 13 (14.4) | 0.013 |
| Febrile neutropenia | ||||
| Grade ≥3 | 12 (8.8) | 8 (17.4) | 4 (4.4) | 0.016 |
| Grade ≥4 | 6 (4.4) | 6 (13.0) | 0 (0.0) | 0.001 |
| Diarrhea | ||||
| Grade ≥3 | 9 (6.6) | 6 (13.0) | 3 (3.3) | 0.040 |
| Grade ≥4 | 3 (2.2) | 3 (6.5) | 0 (0.0) | 0.037 |
| Non-hematological toxicities | ||||
| Grade ≥3 | 38 (27.9) | 18 (39.1) | 20 (22.2) | 0.037 |
| Grade ≥4 | 9 (6.6) | 6 (13.0) | 3 (3.3) | 0.040 |
| Treatment-related mortality | 4 (2.9) | 2 (4.3) | 2 (2.2) | 0.42 |