Fig. 7.

Reduced tumour growth in RhoJ-knockout mice. Wild-type (WT) and RhoJ-knockout (KO) mice were subcutaneously implanted with 10⁶ Lewis lung carcinoma cells, after 2 weeks the tumours were excised and weighed (WT, n = 5; RhoJ KO n = 7). (A) The tumour weights are plotted (mean±s.e.m.). *P = 0.0101 (Mann–Whitney test). (B) The excised tumours were sectioned and vessels stained using anti-CD31 with representative images shown. Scale bar: 100 µm. (C) Vessel density was calculated using the Angiosys Software and plotted (mean±s.e.m.). *P = 0.0303 (Mann–Whitney test).