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A model for RhoJ function. Active RhoJ interacts with the GIT–PIX complex through its interaction with the Spa homology domain (SHD) of GIT1 or GIT2 (GIT). GIT interacts with paxillin and β-PIX. Active RhoJ together with the GIT–PIX complex promote activation of Rac and Cdc42 and focal adhesion disassembly and increased motility. This is associated with decreased RhoA activity and decreased actinomyosin contractility.
