Table 1.

Disease etiologies regulated by 12(S)-HETE and potentially 12-HETER1.

Cancer	**12(S)-HETE:pleiotropic effects: angiogenesis, cell proliferation,migration, invasion, endothelial cell retraction [95,278,279]
	13(S)-HODE: circadian regulation and cancer [280–282]
Zellweger spectrum of peroxisome biogenesis disorders (PBD-ZSD)
	**impaired peroxisome fcn,cells unable to metabolize 12-HETE; blood, organ system metabolism affected, leads to damage of brain white matter [283,284]
Hypertension	**mediation of angiotensin II–induced intracellular calcium transients [223,285,286]
Atherosclerosis	**plaque formation [287,288]
Diabetes	**ischemic/proliferative retinopathy, human islet cell death [223,289–292]
Parkinson’s	** Glutathione (GSH) depletion–related cell death [293,294]
Alzheimer’s	** c-jun-dependent apoptosis pathway, regulates BACE proteolytic pathway [172,295–297]
Neurological functions	**modulates neural peptide secretion, LHRH, the target of chemical castration in PCa treatment, intermediates activate TRPV1 in sensory neurons [298–300]