Table 7. Baseline Characteristics and Metabolic Profiles associated with Mortality.
Died (n = 8) | Survived (n = 54) | ||
Mean±SEM | p-value | ||
Anthropometry (nonedematous) | |||
Admission W/H % | 61.1±4.6 | 72.5±1.0 | 0.0121 |
Admission W/H Z-Score | −6.28±1.05 | −3.98±0.19 | 0.0244 |
Admission W/A Z-Score | −7.01±0.86 | −4.63±0.26 | 0.0221 |
Admission MUAC | 7.8±0.3 | 10.1±0.2 | 0.0019 |
L/A z-score (all patients) | −4.03±0.58 | −2.82±0.18 | 0.0454 |
Fatty Acid Metabolites | |||
NEFA (mmol/L) | 0.57±0.15 | 0.56±0.06 | 0.557 |
Total Ketones (µmol/L) | 539±276 | 526±106 | 0.456 |
Acylcarnitines | |||
C2 (µmol/L) | 16.3±2.2 | 16.5±2.3 | 0.139 |
C3 (µmol/L) | 0.51±0.09 | 0.38±0.03 | 0.128 |
C2/C3 Ratio | 38.5±7.7 | 48.4±5.5 | 0.858 |
Even-Chain Acylcarnitine Molar Sum (µmol/L) | 17.9±2.2 | 18.1±2.5 | 0.139 |
Hormones | |||
Insulin (µIU/ml) | 1.10±0.97 | 2.46±0.38 | 0.182 |
Growth Hormone (ng/ml) | 10.5±3.4 | 11.5±1.3 | 0.442 |
IGF-1 (ng/ml) | 5.6±4.8 | 11.1±1.8 | 0.118 |
Total Ghrelin (pg/ml) | 4660±771 | 3811±297 | 0.361 |
GLP-1 (pg/ml) | 149.1±30.3 | 97.9±11.7 | 0.080 |
PYY (pg/ml) | 1866±227 | 1101±87 | 0.0089 |
Cortisol (µg/dl) | 52.2±6.2 | 47.4±2.4 | 0.484 |
Adipocytokines * | n = 8 | n = 51 | |
Leptin (pg/ml) | 7.1±4.4 | 280±47 | 0.0002 |
Total Adiponectin (ng/ml) | 10403±3360 | 14191±1017 | 0.075 |
HMW Adiponectin (ng/ml) | 4894±1922 | 8795±693 | 0.0184 |
Amino Acids | |||
Amino Acid Molar Sum (µmol/L) | 1248±70 | 1193±46 | 0.319 |
Inflammatory Cytokines | |||
IL-2 (pg/ml) | 16.2±2.8 | 2.9±1.1 | 0.0004 |
IL-6 (pg/ml) | 223.6±47.9 | 17.2±18.4 | 0.166 |
IL-8 (pg/ml) | 323±147 | 105±57 | 0.0042 |
TNF-α (pg/ml) | 46.8±20.2 | 37.6±7.8 | 0.0203 |
*Excludes patients on ARVs.