Table 2. Univariate logistic regression for prediction of high on treatment platelet reactivity (HTPR).
| Variable | HTPR N = 81 (20%) | no HTPR N = 321 (80%) | Regression coefficient | P value | OR | 95% confidence intervals | |
| Age (years) | 63±12 | 64±12 | −0.014 | 0.225 | 0.986 | 0.964 | 1.009 |
| Gender (male) n (%) | 58 (72) | 249 (78) | 0.454 | 0.139 | 1.574 | 0.862 | 2.873 |
| Risk factors/past medical history n (%) | |||||||
| Body mass index (BMI; mean±SD) | 29±5.8 | 28±5.2 | 0.036 | 0.141 | 1.036 | 0.988 | 1.086 |
| Hypertension | 66 (83) | 275 (869 | −0.210 | 0.559 | 0.810 | 0.400 | 1.641 |
| Hyperlipidemia | 60 (75) | 248 (78) | −0.111 | 0.717 | 0.895 | 0.491 | 1.630 |
| Smoking | 46 (58) | 174 (55) | 0.128 | 0.650 | 1.137 | 0.653 | 1.979 |
| Family history of CAD | 21 (26) | 105 (33) | −0.313 | 0.276 | 0.731 | 0.416 | 1.285 |
| Diabetes mellitus | 36 (44) | 97 (30) | 0.724 | 0.011 | 2.063 | 1.178 | 3.614 |
| Peripheral arterial occlusive disease | 9 (11) | 45 (14) | −0.373 | 0.402 | 0.689 | 0.288 | 1.647 |
| Cerebrovascular disease | 7 (9) | 34 (11) | 0.114 | 0.812 | 1.121 | 0.437 | 2.875 |
| Glomerular filtration rate (GFR: mean±SD) | 78 (31) | 85 (37) | 0.006 | 0.137 | 1.006 | 0.998 | 1.014 |
| Medications (%) | |||||||
| Aspirin | 81 (100) | 321 (100) | −0.337 | 0.785 | 0.714 | 0.064 | 7.983 |
| Clopidogrel | 81 (100) | 321 (100) | −41.805 | 0.999 | 0 | 0 | 0 |
| Statins | 63 (80) | 257 (84) | −0.189 | 0.599 | 0.828 | 0.41 | 1.673 |
| β blockers | 65 (83) | 256 (84) | −0.052 | 0.892 | 0.95 | 0.45 | 2.003 |
| Proton pump inhibitors | 68 (87) | 246 (80) | 0.357 | 0.354 | 1.429 | 0.672 | 3.04 |
| Angiotensin converting enzyme inhibitors | 54 (69) | 210 (69) | −0.006 | 0.984 | 0.994 | 0.562 | 1.757 |
| Calcium channel blockers | 10 (13) | 68 (22) | −0.719 | 0.06 | 0.487 | 0.231 | 1.03 |
| PCI data | |||||||
| PCI due to an acute coronary syndrome (ACS) | 40 (50) | 92 (29) | 0.378 | 0.006 | 1.459 | 1.116 | 1.907 |
| Number of stents per patient | 1.86±1.27 | 1.69±0.98 | 0.204 | 0.085 | 1.226 | 0.972 | 1.547 |
| Total stent length | 33.7±24.7 | 31.1±20.9 | 0.005 | 0.36 | 1.005 | 0.994 | 1.016 |
| Genetic data | |||||||
| CYP2C19*17 | 24 (30) | 135 (42) | −0.616 | 0.038 | 0.540 | 0.302 | 0.966 |
| CYP2C19*2 | 33 (41) | 90 (28) | 0.477 | 0.070 | 1.611 | 0.929 | 2.796 |
| ABCB1 C3435T | 63 (77) | 250 (77) | 0.057 | 0.859 | 1.059 | 0.561 | 1.997 |
| PON1 Q192R | 40 (49) | 160 (50) | −0.147 | 0.592 | 0.864 | 0.505 | 1.476 |
ACS: acute coronary syndrome; BMI: body mass index; GFR: glomerular filtration rate; CAD: coronary artery disease; CYP: cytochrome P450; ABCB1: gene encoding transmembrane transporter P-glycoprotein; PON1: paroxonase 1.