Table 3. Path modelling results.

dependent variable		path precursor	standardized estimate/path coefficient	standard error	P value
HTPR	<---	CYP2C19*2	0.165	2.814	0.001
	<---	CYP2C19*17	−0.103	2.643	0.035
	<---	ABCB1 C3435T	−0.010	3.092	0.838
	<---	PON1 Q192R	0.039	2.577	0.417
	<---	ACS at admission	0.109	1.305	0.025
	<---	Diabetes mellitus	0.096	2.755	0.048
	<---	BMI	0.062	0.244	0.207
	<---	GFR	−0.009	2.384	0.850
	<---	Smoking	0.047	2.612	0.333
	<---	Age	0.023	0.104	0.638
MACE	<---	CYP2C19*2	0.012	0.037	0.803
	<---	CYP2C19*17	0.034	0.034	0.497
	<---	ABCB1 C3435T	−0.040	0.040	0.418
	<---	PON1 Q192R	0.019	0.033	0.694
	<---	ACS at admission	0.014	0.036	0.770
	<---	Diabetes mellitus	0.033	0.017	0.508
	<---	BMI	0.041	0.003	0.409
	<---	GFR	0.061	0.031	0.224
	<---	Smoking	0.080	0.034	0.104
	<---	Age	0.141	0.001	0.004
	<---	HTPR	0.126	0.001	0.016

ACS: acute coronary syndrome; BMI: body mass index; GFR: glomerular filtration rate; CYP: cytochrome P450; ABCB1: gene encoding transmembrane transporter P-glycoprotein; PON1: paroxonase 1; HTPR: high on treatment platelet reactivity; MACE: major adverse cardiac events (MACE: the composite of acute coronary syndrome, stent thrombosis and cardiac death).