Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Jul 22;9(7):e103033. doi: 10.1371/journal.pone.0103033

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2014 Chen et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

(A) Docking of C22-ceramide to I2PP2A/SET. The surface contour was colored by electrostatic potential. The atoms of C22-ceramide were shown as sticks. (B) The binding mode of C22-ceramide with I2PP2A/SET. C22-ceramide and the residues involved in the interactions with C22-ceramide are shown as sticks. The hydrogen bonds formed between C22-ceramide and I2PP2A/SET were shown as black dashes. (C) Binding modes between I2PP2A/SET and ceramide with various chain lengths predicted by molecular docking. Front and rear direction views show the bond ceramide composed sphingosine and fatty acid chains.