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. 2014 Jul 15;9:3377–3387. doi: 10.2147/IJN.S66368

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© 2014 Li et al. This work is published by Dove Medical Press Ltd, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Ltd, provided the work is properly attributed.

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Photographic images of the skin wounds in diabetic models after treatment for various amounts of time (0–7 days).

Notes: Treatments were (A) buffer solution; (B) MMP-9-siRNA alone; (C) β-CD-(D₃)₇ alone; or (D) β-CD-(D₃)₇/MMP-9-siRNA complexes (mass ratio =20). The amounts of MMP-9-siRNA alone and β-CD-(D₃)₇ alone were the same as those in β-CD-(D₃)₇/MMP-9-siRNA complexes (mass ratio =20). The mortality rates for the treatments were 25.0% (A), 25.0% (B), 35.3% (C), and 33.3% (D).

Abbreviations: β-CD-(D₃)₇, a cationic star-shaped polymer consisting of a β-cyclodextrin core and poly(amidoamine) dendron arms; MMP-9, matrix metalloproteinase-9; siRNA, small interfering RNA.