Figure 8.

Wound closure percentage in diabetic models after treatment for different amounts of time (4 or 7 days).

Notes: Treatments: I = buffer solution; II = MMP-9-siRNA alone; III = β-CD-(D₃)₇ alone; IV = β-CD-(D₃)₇/MMP-9-siRNA complexes (mass ratio =20). The amounts of MMP-9-siRNA alone and β-CD-(D₃)₇ alone were the same as in β-CD-(D₃)₇/MMP-9-siRNA complexes (mass ratio =20). The mortality rates were 25.0% for treatment I; 25.0% for treatment II; 35.3% for treatment III; and 33.3% for treatment IV. *Compared to control group P<0.05.

Abbreviations: β-CD-(D₃)₇, a cationic star-shaped polymer consisting of a β-cyclodextrin core and poly(amidoamine) dendron arms; MMP-9, matrix metalloproteinase-9; siRNA, small interfering RNA.