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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Stem Cells. 2014 Aug;32(8):2267–2277. doi: 10.1002/stem.1715

Figure 4. Wnt pathway is not active in minor SG LRCs, whereas Sonic hedgehog signals predominantly to stromal cells.

Figure 4

View of soft palate of Tcf/Lef:H2B-GFP reporter mice (A) and Gli1CreER/RosaZsGreen mice 1 month after Tamoxifen induction (C). Side view sections of soft palate of Tcf/Lef:H2B-GFP reporter mice (B) and Gli1CreER/RosaZsGreen mice 1 month after Tamoxifen induction (D). Shown are epifluorescence of H2B-GFP (green) or ZsGreen and 4’,6’-diamidino-2-phenylindole (DAPI) (blue), and indirect immunofluorescence with antibody as indicated (Red). Arrows in A and B denote Tcf/Lef1:H2BGFP positive cells localized in the upper duct of minor salivary gland and epithelium of soft palate. Arrows in C and D denote Shh responsive cells in the stroma surrounding the minor SG, whereas arrow head indicate Shh responsive cells localized in the upper duct of minor SG. Scale bar: B and D 50µm. Abbreviations: ep, epithelium; SP, soft patale; HP, hard palate.