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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Neuropharmacology. 2014 May 21;85:67–72. doi: 10.1016/j.neuropharm.2014.05.006

Figure 2. Effects of methoxsalen on nicotine precipitated withdrawal in the mouse.

Figure 2

Nicotine was administered at 2 mg/kg (s.c.) 15 min after pretreatment with vehicle or methoxsalen (15 mg/kg, i.p.) three times daily for 4 days. On test day (5th day), mice received one last dose of nicotine and 1 h later they were injected with mecamylamine (2 mg/kg, s.c.). Ten min later, (A) somatic signs (B) anxiety-related behaviors and (C) hyperalgesia were measured in the mice. Data are presented as the mean ± SEM of 5–7 animals. **p<0.01, ***p<0.001 vs its control and ##p<0.01, ###p<0.001 vs vehicle + nicotine. (MOP = methoxsalen)