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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Neuropharmacology. 2014 May 21;85:67–72. doi: 10.1016/j.neuropharm.2014.05.006

Table 2.

Total number of crossovers in the plus-maze test after precipitated nicotine withdrawal in mice. Nicotine was administered at 2 mg/kg (s.c.) 15 min after pretreatment with vehicle or methoxsalen (15 mg/kg, i.p.) three times daily for 4 days. On test day (5th day), mice received one last dose of nicotine and 1 h later they were injected with mecamylamine (2 mg/kg, s.c.). Ten min later, the total number of crossovers in the plus-maze test was measured in the different groups for 5 min. Data are presented as the mean ± SEM of 5–7 animals.

Treatment Groups Number Crossovers
(Mean ± SEM)
Vehicle Control 6.3 ± 0.5
Vehicle / Nicotine / Mecamylamine 5.5 ± 0.8
Methoxsalen / Vehicle/ Mecamylamine 6.0 ± 0.8
Methoxsalen / Nicotine / Mecamylamine 6.2 ± 0.6