Table 3.
Week 0–24 Changes | Week 0–48 Changes | Week 24–48 Changes | Pooled 24-week Changes | ||||||
---|---|---|---|---|---|---|---|---|---|
Immediate | Delayed | Between Group p |
Immediate | Within Group p |
Delayed | Within Group p |
Immediate 0–24 weeks Delayed 24–48 weeks |
Within Group p |
|
N | 17 | 20 | 17 | ||||||
sCD14 (ng/mL) | −461.9 (−704.0, −253.7)* | −102.6 (−277.4, 107.6) | 0.003 | −494.1 (−764.8, −269.4) | <0.0001 | −217.6 (−498.8, 14.4) | 0.006 | −308.9 (−704.0, −97.0) | <0.0001 |
sCD163 (ng/mL) | 29.4 (−71.6, 98.0) | −27.5 (−44.8, 36.8) | 0.34 | 3.0 (−84.2, 94.0) | 1.00 | 70.6 (−7.0, 165.7) | 0.05 | 49.8 (−26.7, 125.4) | 0.05 |
I-FABP (pg/mL) | −150.1 (−380.4, 173.3) | 250.2 (−379.7, 948.9) | 0.16 | −93.5 (−347.9, 227.3) | 0.75 | 261.2 (−110.6, 1341.2) | 0.08 | 149.7 (−380.4, 885.9) | 0.37 |
IL-6 (pg/mL) | 0.5 (−0.9, 1.3) | −0.5 (−2.0, 0.3) | 0.16 | −0.2 (−0.4, 0.7) | 0.67 | 0.0 (−0.6, 1.0) | 0.77 | 0.3 (−0.9, 1.1) | 0.48 |
D dimer (µg/mL) | −0.1 (−0.2, 0.0) | 0.0 (−0.1, 0.1) | 0.29 | 0.0 (−0.1, 0.1) | 0.87 | 0.1 (−0.1, 0.2) | 0.31 | 0.0 (−0.1, 0.1) | 0.80 |
TNF-α (pg/mL) | 0.3 (−0.2, 0.6)* | −0.1 (−0.9, 0.3) | 0.05 | 0.1 (−0.9, 0.9) | 0.81 | 0.2 (−0.1, 0.9) | 0.15 | 0.3 (−0.2, 0.8) | 0.01 |
sTNF-RII (pg/mL) | 16.5 (−76.4, 236.1) | −195.7 (−333.6, −47.9)* | 0.005 | 12.8 (−415.8, 195.4) | 0. 46 | 73.9 (−197.8, 207.2) | 1.00 | 59.2 (−172.4, 218.4) | 0.66 |
sVCAM-1 (ng/mL) | −1.5 (−170.2, 30.8) | −46.0 (−173.2, 76.9) | 0.99 | −2.7 (−169.9, 39.1) | 0.16 | −1.9 (−41.0, 61.1) | 1.00 | −1.8 (−95.0, 59.7) | 0.38 |
CTP (µg/L) | 0.1 (−0.6, 0.8) | 0.1 (−0.3, 0.4) | 0.84 | −0.0 (−0.7, 0.6) | 0.91 | 0.3 (−0.5, 0.7) | 0.44 | 0.2 (−0.6, 0.7) | 0.47 |
P1NP (µg/L) | 4.0 (−7.6, 12.9) | −4.0 (−15.1, 4.8) | 0.31 | −2.5 (−18,9, 1.8) | 0.08 | 0.0 (−23.8, 4.5) | 0.46 | 0.6 (−13.9, 9.4) | 0.90 |
Median within-person change scores shown with interquartile range. Wilcoxon rank sum test used for determination of statistical significance. Two-sided α=0.05. sCD14=soluble CD14; sCD163=soluble CD163; I-FABP=intestinal-type fatty acid binding protein; IL-6=interleukin-6; TNF-α=tumor necrosis factor-α; sTNF-RII=soluble tumor necrosis factor receptor II; sVCAM-1=soluble vascular cell adhesion molecule-1; CTP=C-telopeptide; P1NP=pro-collagen type 1 N-terminal pro-peptide.
Within group p<0.05.