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. Author manuscript; available in PMC: 2014 Aug 15.

Published in final edited form as: Stat Med. 2014 Apr 14;33(18):3100–3113. doi: 10.1002/sim.6164

Table 1.

Coverage probability of the naive confidence interval and power of the naive test for marker-treatment interaction:

(N = 200, ξ_G = 0.4)^†
	π₁=0·80	0·85	0·90	0·95
π₀= 0·80	0·74/0·46	0·78/0·52	0·82/0·58	0·85/0·64
0·85	0·80/0·53	0·83/0·59	0·86/0·65	0·89/0·70
0·90	0·85/0·61	0·88/0·66	0·90/0·71	0·91/0·76
0·95	0·90/0·69	0·91/0·73	0·93/0·78	0·94/0·82
(N = 200, ξ_G = 0.6)^†
	π₁=0 ·80	0·85	0·90	0·95
π₀= 0·80	0·74/0·46	0·80/0·53	0·85/0·61	0·90/0·69
0·85	0·78/0·52	0·83/0·59	0·88/0·66	0·91/0·73
0·90	0·82/0·58	0·86/0·65	0·90/0·71	0·93/0·78
0·95	0·85/0·64	0·89/0·70	0·91/0·76	0·94/0·82
(N = 400, ξ_G = 0.4)^††
	π₁=0·80	0·85	0·90	0·95
π₀= 0·80	0·54/0·75	0·61/0·81	0·68/0·86	0·75/0·91
0·85	0·65/0·82	0·71/0·87	0·76/0·91	0·82/0·94
0·90	0·75/0·88	0·80/0·92	0·84/0·95	0·88/0·97
0·95	0·85/0·93	0·88/0·96	0·90/0·97	0·92/0·98
(N = 400, ξ_G = 0.6)^††
	π₁=0·85	0·90	0·95	0·99
π₀= 0·80	0·54/0·75	0·65/0·82	0·75/0·88	0·85/0·93
0·85	0·61/0·81	0·71/0·87	0·80/0·92	0·88/0·96
0·90	0·68/0·86	0·76/0·91	0·84/0·95	0·90/0·97
0·95	0·75/0·91	0·82/0·94	0·88/0·97	0·92/0·98

^†

power=0.90 if no misclassification;

^††

power=0.99 if no misclassification.