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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Eur J Neurosci. 2014 Mar 27;40(1):2264–2273. doi: 10.1111/ejn.12571

Figure 5.

Figure 5

Pharmacologically increasing or decreasing endogenous GABA levels in the pontine reticular nucleus, oral part (PnO) altered thermal nociception. Microinjection of the GABA synthesis inhibitor 3-mercaptopropionic acid (3-MPA) significantly increased %MPE, reflecting decreased thermal nociception (A). Time course of thermal nociception during 2 h after a microinjection of 3-MPA (B). Administration of the GABA uptake inhibitor nipecotic acid (NPA) significantly decreased %MPE, indicating increased thermal nociception (C). Time course of the effect on thermal nociception during 2 h after microinjection of NPA (D). Time 0 on the abscissa indicates the end of the 1-min period during which Ringer’s or drug was microinjected into the PnO. Asterisks (*) indicate significant differences from control (Ringer’s). The § symbol in B indicates P = 0.0545.