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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Eur J Neurosci. 2014 Mar 27;40(1):2264–2273. doi: 10.1111/ejn.12571

Figure 6.

Figure 6

Microinjection of a GABA synthesis inhibitor into rat pontine reticular nucleus, oral part (PnO) reversed the hyperalgesia caused by sleep deprivation. A. Sleep deprivation significantly decreased %MPE (i.e., increased thermal nociception). PnO administration of 3-mercaptopropionic acid (3-MPA) significantly increased %MPE, preventing the increase in nociception caused by sleep deprivation. B. Time course of %MPE during 4 h as a function of drug, sleep, and time after PnO microinjection. Administration of 3-MPA caused a significant increase in %MPE during the 4-h testing period. Time 0 on the abscissa indicates the end of the 1-min period during which Ringer’s or 3-MPA was microinjected into the PnO. Asterisks (*) indicate significant differences from sleep deprivation. Pound symbol (#) indicates significant differences from ad libitum sleep.