Table II.

Adverse Events on Southwest Oncology Group Protocol S0433. Any Grade 4 or Grade 5 and Common (in 10% of patients or more) Grade 3 Events.

Adverse Events	n, % of Patients (total n=84)
(grade ≥ 3)	Grade 3	Grade 4	Grade 5
Cardiovascular	6 (7%)	1 (1%)	2* (2%)
Flu-like symptoms	11 (13%)	1 (1%)	--
Dehydration	--	1 (1%)	--
Other Gastrointestinal Event	--	1 (1%)	--
Haematological
Haemoglobin	12 (14%)	--	--
Leucocytes	23 (27%)	24 (29%)	--
Lymphopenia	24 (29%)	15 (18%)	--
Neutrophils	11 (13%)	44 (52%)	--
Platelets	12 (14%)	17 (20%)	--
GI Haemorrhage: rectum	--	1 (1%)	--
Infection	20 (24%)	1 (1%)	1* (1%)
Pneumonitis	--	1 (1%)	--
Hyperglycaemia	--	1 (1%)	--
Hyperuricaemia	--	1 (1%)	--
Hypokalaemia	--	1 (1%)	--
Neurophathy	9 (11%)	--	--
Renal Failure	--	--	1* (1%)
Secondary Malignancy	1 (1%)	--	1* (1%)

^*2 cardiac ischaemia, 1 febrile neutropenia, 1 renal failure, 1 acute myeloid leukaemia GI, gastrointestinal