Table 3.

Plasma clot formation and fibrinolysis parameters

	Controls (n=10)	Non-bleeders (n=8)	Bleeders (n=8)	P ANOVA	P* Controls vs Non-Bleeders	P* Controls vs Bleeders	P* Bleeders vs Non-Bleeders
Clotting
Onset Time (minutes)	13.4 ± 7.8	16.0 ± 7.4	23.8 ± 16.9	0.16	–	–	–
Vmax (mOD/minute)	143.4 ± 67.5	43.3 ± 16.9	32.4 ± 25.5	<0.0001	0.0003	<0.0001	1
Time to Plateau (minutes)	28.4 ± 15.3	47.4 ± 17.4	74.5 ± 37.4	<0.003	0.34	<0.003	0.14
Peak Turbidity Change	0.69 ± 0.14	0.68 ± 0.13	0.56 ± 0.11	0.07	–	–	–
Fibrin density (A.U.)	222786 ± 37171	234574 ± 42621	177387 ± 22610	<0.008	1	<0.05	<0.02
Fibrinolysis
Onset Time (minutes)	15.8 ± 8.8	11.6 ± 4.1	17.0 ± 6.1	0.28	–	–	–
Vmax (mOD/minute)	166.0 ± 50.0	49.5 ± 12.5	39.5 ± 16.6	<0.0001	<0.0001	<0.0001	1
Time to Peak (minutes)	27.0 ± 11.3	32.2 ± 7.4	43.2 ± 17.3	<0.05	1	<0.05	0.28
Lysis Time$ (minutes)	36.3 ± 11.4	29.9 ± 5.6	23.7 ± 3.5	<0.02	0.32	<0.01	0.39
Peak Turbidity Change	0.64 ± 0.11	0.58 ± 0.14	0.40 ± 0.12	<0.002	0.83	<0.002	<0.05
Area under the Curve	1482 ± 530	1176 ± 386	673 ± 210	<0.002	0.39	<0.002	<0.07

Mean±SD

^*ANOVA with Bonferroni post-hoc test

^$Length of time between the midpoints of the increase and decrease in turbidity