– NT involvement in mephedrone self-administration. As described in materials and methods, rats were food-trained, jugular catheters were implanted, and then allowed to self-administer mephedrone (0.24 mg mephedrone/infusion, FR1) for 7 d. On day 6, the neurotensin receptor-1 agonist PD149163 (0.5 mg/kg, i.p.) was given 15 min prior to the self-administration session. *p < 0.05 vs. day 5 lever presses.