Table 4.

Association between a parental history of autoimmune and allergic disease and childhood and adolescent Hodgkin lymphoma overall and by EBV status^*,†

	Combined cases				EBV+				EBV−
	Ncontrols	Ncases	OR†	95% CI	Ncontrols	Ncases	OR†	95% CI	Ncontrols	Ncases	OR†	95% CI
Autoimmune diseases in parents
Any autoimmune disease‡	153	122	1.17	0.87, 1.58	23	23	2.97	1.34, 6.58	83	61	0.88	0.58, 1.35
None	587	376	Ref		133	59	Ref		275	200	Ref
Arthritis	88	67	1.05	0.72, 1.54	9	14	7.79	2.37, 25.63	45	33	0.82	0.48, 1.41
None	652	431	Ref		147	68	Ref		313	228	Ref
Diabetes§	27	24	1.35	0.73, 2.50	3	5	5.40	0.82, 35.44	18	12	0.86	0.38, 1.96
None	713	474	Ref		153	77	Ref		340	249	Ref
Psoriasis	40	29	1.15	0.65, 2.02	9	6	1.29	0.35, 4.76	23	12	0.71	0.31, 1.65
None	700	469	Ref		147	76	Ref		335	249	Ref
Other autoimmune	4	10	2.75	0.73, 10.41	1	0	-	-	2	9	5.64	1.09, 29.17
None	736	488	Ref		155	82	Ref		356	252	Ref
Allergic diseases in parents
Any allergy∥	426	287	1.14	0.88, 1.48	84	44	1.00	0.51, 1.96	201	163	1.47	1.01, 2.14
None	314	211	Ref		72	38	Ref		157	98	Ref
Number of allergies∥
0	314	211	Ref		72	38	Ref		157	98	Ref
1	210	133	1.00	0.73, 1.36	38	18	0.86	0.38, 1.96	102	71	1.19	0.77, 1.85
2	124	96	1.44	1.01, 2.06	28	14	0.99	0.37, 2.68	55	56	1.94	1.18, 3.18
3+	92	58	1.08	0.71, 1.65	18	12	1.50	0.50, 4.54	44	36	1.60	0.88, 2.91
P trend			0.22				0.77				0.02
Asthma	103	72	1.21	0.85, 1.73	20	16	2.26	0.90, 5.66	46	40	1.38	0.84, 2.29
None	637	426	Ref		136	66	Ref		312	221	Ref
Eczema	74	55	1.14	0.75, 1.74	18	7	0.65	0.21, 1.99	30	35	1.75	0.94, 3.26
None	666	443	Ref		138	75	Ref		328	226	Ref
Hay fever	265	179	1.18	0.91, 1.54	50	30	1.47	0.74, 2.90	126	95	1.19	0.83, 1.72
None	475	319	Ref		106	52	Ref		232	166	Ref
Hives	170	124	1.18	0.88, 1.58	32	23	1.32	0.62, 2.80	85	74	1.39	0.92, 2.10
None	570	374	Ref		124	59	Ref		273	187	Ref
Contact dermatitis	50	30	0.81	0.48, 1.37	12	3	0.33	0.07, 1.49	23	19	0.98	0.50, 1.94
None	690	468	Ref		144	79	Ref		335	242	Ref
Other allergy	94	61	1.04	0.70, 1.54	20	9	0.88	0.26, 2.92	46	41	1.41	0.84, 2.38
None	646	437	Ref		136	73	Ref		312	220	Ref

OR = odds ratio; 95% CI = 95% confidence interval

^*Numbers in tables may not sum to total number of cases/controls due to missing values.

^†ORs adjusted for household income at birth, maternal age at the child’s birth, mother’s education, and birth order of index child (considering full and half siblings)

^‡Any autoimmune disease variable includes: arthritis, Crohn’s disease, diabetes, lupus erythematosus, multiple sclerosis, Myasthenia Gravis, psoriasis, scleroderma, other autoimmune disease. Less than five cases had one or more parents with the autoimmune conditions: Crohn’s disease (2 cases, 6 controls), lupus erythematosus (2 cases, 3 controls), multiple sclerosis (0 cases, 1 control), Myasthenia Gravis (1 case, 1 control), pernicious anemia (2 cases, 1 control), scleroderma (0 cases, 0 controls),.

^§Includes both type I and type II diabetes; information regarding type was not requested in the questionnaire.

^∥Any allergy and number of allergies variables include: asthma, eczema, hay fever, hives, contact dermatitis, other allergy.