Table 1.
Cellular and physiological functions.a
| Category | Functional Annotation | p Value | Activation z score | |
|---|---|---|---|---|
| RT | Cell death and survival | apoptosis | 4.14E-12 | −1.285 |
| necrosis | 8.00E-12 | −0.863 | ||
| cell death | 4.68E-10 | −1.104 | ||
| cell death of connective tissue cells | 6.76E-10 | 0.515 | ||
| cell survival | 9.86E-08 | 2.742 | ||
| Cell cycle | arrest in interphase | 5.19E-11 | ||
| interphase | 2.26E-10 | 0.512 | ||
| cell cycle progression | 6.63E-09 | 2.092 | ||
| G1 phase | 3.74E-07 | −0.018 | ||
| Gene expression | binding of DNA | 4.58E-10 | −0.274 | |
| transcription of RNA | 1.01E-07 | 0.441 | ||
| binding of protein binding site | 3.47E-07 | 0.839 | ||
| expression of RNA | 5.59E-07 | 0.914 | ||
| expression of DNA | 5.96E-06 | 1.485 | ||
| Cellular growth, development and proliferation | proliferation of cells | 7.07E-09 | 0.710 | |
| proliferation of connective tissue cells | 4.59E-08 | 1.905 | ||
| differentiation of connective tissue cells | 6.38E-08 | 2.668 | ||
| differentiation of cells | 2.20E-07 | 1.256 | ||
| HBOT | Cellular function and maintenance | function of leukocytes | 2.57E-14 | −0.751 |
| function of blood cells | 3.58E-13 | −0.751 | ||
| function of mononuclear leukocytes | 1.20E-09 | −0.684 | ||
| function of lymphocytes | 3.20E-09 | −0.684 | ||
| Cellular movement | chemotaxis of leukocytes | 1.46E-11 | −3.641 | |
| cell movement of leukocytes | 1.68E-11 | −4.942 | ||
| homing of leukocytes | 4.30E-11 | −3.753 | ||
| chemotaxis of myeloid cells | 6.64E-11 | −3.110 | ||
| Cellular development | proliferation of lymphocytes | 2.00E-10 | −2.036 | |
| proliferation of immune cells | 7.99E-10 | −2.268 | ||
| proliferation of blood cells | 1.45E-09 | −2.083 | ||
| Cell-to-cell signaling and interaction | activation of cells | 2.32E-10 | −3.952 | |
| activation of leukocytes | 3.17E-10 | −4.119 | ||
| activation of blood cells | 2.04E-09 | −3.932 | ||
| RT + HBOT | Cellular growth, development and proliferation | proliferation of cells | 6.44E-08 | 2.676 |
| proliferation of fibroblast cell lines | 4.57E-05 | 0.873 | ||
| differentiation of connective tissue cells | 1.52E-04 | 2.074 | ||
| formation of cells | 1.95E-04 | 0.528 | ||
| proliferation of connective tissue cells | 4.71E-04 | 1.728 | ||
| Cell death and survival | necrosis | 3.13E-06 | −0.182 | |
| cell death | 7.26E-06 | −0.101 | ||
| apoptosis | 8.46E-06 | −0.521 | ||
| cell viability of fibroblasts | 3.66E-04 | 0.647 | ||
| Cell cycle | arrest in G1 phase | 6.09E-05 | ||
| polyploidization of cells | 1.30E-04 | −0.640 | ||
| arrest in interphase | 1.77E-04 | |||
| Cellular function and maintenance | transport of D-glucose | 3.38E-05 | 2.419 | |
| concentration of D-glucose | 8.41E-05 | −0.491 | ||
| quantity of carbohydrate | 2.69E-04 | 0.585 |
a
Cellular and physiological functions that are affected by RT, HBOT and RT + HBOT, divided into categories. z Scores of <2 (inhibition) or >2 (activation) are considered statistically significant.