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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Pathog Dis. 2014 May 16;71(2):263–273. doi: 10.1111/2049-632X.12176

Figure 1. Rats develop fever prior to 48 hours post-infection and enter hypothermia in the end stage of disease.

Figure 1

A) Inhalation exposure challenge with 100x mean lethal dose (MLD) of Y. pestis CO92 (6×105 CFU presented dose) in male and female Brown Norway rats with abdominal telemeter implants. Rats were monitored for 7 days; lethality occurred in less than 4 days. B) Period analysis by body temperature (Tb). Mean temperature recordings by the hour as monitored by telemetry implant. Monitoring began 22 hours prior to infection (baseline) and the first 72 hours post-infection are shown (n=9 males, 18 females). All animals were analyzed for statistical significance by period set at P<0.0001. Dashed line between asymptomatic and fever stages as well as fever and hypothermic stages indicates statistical significance between groups. Error bars represent the standard error of the mean.