(A) The predicted amino acid sequences from human, mouse, chicken, zebrafish, Xenopus tropicalis, Xenopus laevis Tfap2e and Xenopus laevis Tfap2a, Tfap2c and Tfap2d genes were aligned using ClustalX2. Amino acid conservation among Tfap2 family members has been color-coded. Tfap2 DNA binding domain is underlined. (B) Phylogenetic tree analysis of Tfap2a, Tfap2b, Tfap2c, Tfap2d and Tfap2e proteins from Xenopus laevis (Xl), mouse (Mm), chicken (Gg) and zebrafish (Dr).