Table 4.
Summary of strain differences in development of tolerance and sensitization to ethanol’s effect on activity.
| Change over trials in Ethanol response [E4 – E1] | Change over trials in Ethanol-Saline difference [Tol/Sens] | |||
|---|---|---|---|---|
| Strain | 2 g/kg | 4 g/kg | 2 g/kg | 4 g/kg |
| 129P3/J | TA | SD | TA | TD |
| A/HeJ | TA | TD | - | TD |
| AKR/J | - | - | - | TD |
| BALB/cJ | SA | - | SA | TD |
| C3H/HeJ | TA | TA | TA | TA |
| C57BL/6J | TA | - | TA | TD |
| C57L/J | TA | SD | TA | TD |
| C58/J | TA | - | - | - |
| CBA/J | TA | - | - | - |
| DBA/1J | - | - | SA | TD |
| DBA/2J | SA | TD | SA | TD |
| NZB/B1NJ | - | - | - | TD |
| PL/J | - | - | - | - |
| SJL/J | TA | - | TA | TD |
| SWR/J | TA | - | TA | - |
T = Tolerance; S = Sensitization; - = no change over trials
A = Activating effect; D = Depressant effect