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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Chem Biol Drug Des. 2014 May 13;84(2):140–147. doi: 10.1111/cbdd.12303

Scheme 2.

Scheme 2

Enzymatic modification of a CAAX-box containing peptide with trans-cyclooctene geranyl diphosphate (2) and subsequent tetrazine ligation with dipyridyl-tetrazine (3).