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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: J Comp Neurol. 2014 Sep 1;522(13):3120–3137. doi: 10.1002/cne.23582

Figure 5.

Figure 5

Quantitative analysis of Beclin-1 immunoexpression in capillary endothelium in the rat brain 30 days after tMCAO. A: Schematic representation of analyzed areas in the striatum and motor cortex in the ipsilateral and contralateral hemispheres. B: Significant (p<0.0001) upregulation of Beclin-1 immunoexpression was detected in ipsilateral lateral (L), dorsal (D), and ventral (V) striatum areas of post-stroke rats compared to controls. In contralateral striatum, significant (p<0.0001) increase of Beclin-1 fluorescent expression was determined in area V, although elevation of protein expression was demonstrated in medial (M), L, and D areas vs. controls. C: In motor cortex, significant increase of Beclin-1 immunoexpression in capillary endothelium was determined in M2 (p=0.0005) and M1 (p<0.0001) areas in the ipsilateral hemisphere. Overexpression of Beclin-1 in contralateral motor cortex was noted in M2 area. More extensive Beclin-1 upregulation showed in capillary ECs of ipsilateral M1 (p=0.0012) than in M2 and in comparison to contralateral M2 (p=0.0004) and M1 (p<0.0001) motor cortex areas.