Table 4.

Linear regression analysis, afe and animal/human oral bioavailability ratio.

Species	Number of points	Slope (β)	Intercept (α)	R2	ccc	afe	Median RA/H	5% lower percentile for RA/H	95% upper Percentile for RA/H
All	318	0.553⁎	33.114	0.342	0.548	0.647	0.866	0.082	2.771
Mouse	30	0.507⁎⁎	39.478	0.253	0.444	0.593	0.784	0.058	2.784
Rat	122	0.544⁎	35.759	0.287	0.470	0.583	0.723	0.075	2.777
Dog	125	0.580⁎	26.433	0.374	0.605	0.845	0.990	0.236	3.254
NHP	41	0.691⁎	32.942	0.694	0.698	0.417	0.592	0.051	1.042

Regression equation, F_Human = β * F_{Animal,species} + α; R², coefficient of determination; ccc, concordance correlation coefficient; afe, average fold error; R_A/H, animal and human oral bioavailability ratio.

^⁎p value vs. constant model < 0.001.

^⁎⁎p value vs. constant model < 0.005.