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. 2014 Jul 20;4(9):953–959. doi: 10.7150/thno.9265

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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A. Principal Component Analysis (PCA), PC1 vs. PC2. Score plot shows separation between Fetal Growth Restriction (FGR) Cases (red) and Controls (green) based on metabolites abundance significantly different (p<0.01) between the groups. B. Multivariate ROC curve, based on metabolites which were statistically different between Control and FGR Case groups (p<0.01). Var. designated as number of discriminating metabolites (lactate, levulinate, 2-methyloctadecanate, tyrosine, margarate; significance to the model decreasing as listed) included in the AUC (Area Under the Curve) calculations.