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. 2014 Aug;7(8):941–951. doi: 10.1242/dmm.015974

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© 2014. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 1. — Mutation burden and cancer incidence. (A) Comparison of the mean number of non-coding mutations per genome in tumours of different tissues (raw data from Lawrence et al., 2013). Error bars show the standard error of the mean. (B) UK annual incidence of various malignancies [Cancer Registry Statistics, 2011; (www.ons.gov.uk) and the Cancer Research UK website (www.cancerresearchuk.org/cancer-info/cancerstats/)]. An asterisk (*) signifies that the incidence data refer to the tissue of origin, rather than the specific cancer subtype shown in A (e.g. lung cancer rather than lung squamous cell or adenocarcinoma). CLL, chronic lymphocytic leukaemia; DLBCL, diffuse large B-cell lymphoma.