Simulating the experimentally observed rate of up-state spiking required correlation among spike trains. (A) Change in up-state spike rate vs correlation. (B) Sample of up-state spike rate for uncorrelated (c=0.0) and correlated (c=0.5) Poisson input spike trains. The correlation parameter, c = f(N) (Ns = N + ācĀ·(1āN)), where Ns is number of independent Poisson spike trains, and N is the number of synapses (Rudolph and Destexhe, 2001). (C) Sample of up-state spiking from data collected in Blackwell et al. (2003), cell FS07102, which had a mean spikes-per-up-state of 0.62. (D) Expanded view of a simulated (left) and experimental (right) up-state. The selected up-states are indicated with * in panels B, C.