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. 2014 Jul 23;34(30):9845–9856. doi: 10.1523/JNEUROSCI.5161-13.2014

Figure 4.

Figure 4.

Reduced Trpa1 mRNA levels in DRG sections of SNS-gp130−/− mice. A, ISH with Trpa1 antisense riboprobe produced a selective staining of Trpa1-expressing neurons, whereas sense probes did not show specific staining in the lumbar DRG sections. Scale bar, 50 μm. B, Samples of gp130fl/fl and SNS-gp130−/− lumbar DRG sections with Trpa1 antisense riboprobe display reduced Trpa1 mRNA labeling in SNS-gp130−/− sections. Scale bar, 50 μm. C, Quantification of the ISH labeling in lumbar gp130fl/fl and SNS-gp130−/− sections. SNS-gp130−/− sections reveal significantly lower numbers of Trpa1 expressing neurons. *p < 0.05.