Table 3.

Experiment 2: Animal attrition and incidence and timing of autophagia

Rat	Group	Day of onset	Site	Relative to vectora	Severity
27	shPTEN-Fibrin	4	Forepaw	Contralateral	Mild
31	Untreated	4	Forepaw	Contralateral	Severe
33	shPTEN-Fibrin	7	Forepaws	Both	Moderate
18	shPTEN-Fibrin	11	Forepaw	Contralateral	Severe
8	shPTEN/shSOCS3-Fibrin	13	Forepaw	Contralateral	Mild
37	shPTEN/shSOCS3-Fibrin	13	Forepaw	Contralateral	Moderate
8	shPTEN/shSOCS3-Fibrin	14	Forepaw	Ipsilateral	Mild
14	shPTEN-Fibrin	14	Forepaw	Ipsilateral	Mild
19	shPTEN-Fibrin	14	Forepaw	Contralateral	Mild
5	Untreated	15	Forepaw	Contralateral	Mild
2	shPTEN/shSOCS3-Fibrin	19	Hindpaw	Contralateral	Mild
25	Untreated	22	Forepaw	Ipsilateral	Mild
9	shPTEN/shSOCS3-Fibrin	24	Forepaw	Contralateral	Mild
24	shPTEN-Fibrin	24	Hindpaw	Contralateral	Moderate
26	shPTEN/shSOCS3-Fibrin	24	Forepaw	Contralateral	Moderate
40	Untreated	28	Hindpaw	Contralateral	Severe
10	Untreated	29	Hindpaw	Ipsilateral	Mild
41	shPTEN/shSOCS3-Fibrin	30	Forepaw	Contralateral	Mild
46	shPTEN/shSOCS3-Fibrin	30	Hindpaw	Ipsilateral	Mild
18	shPTEN-Fibrin	31	Hindpaw	Ipsilateral	Moderate
21	Untreated	34	Forepaw	Ipsilateral	Mild
12	shPTEN-Fibrin	35	Hindpaw	Contralateral	Mild
30	Untreated	39	Forepaw	Contralateral	Moderate
4	shPTEN-Fibrin	46	Hindpaw	Contralateral	Mild
34	shPTEN-Fibrin	48	Forepaw	Contralateral	Mild
44	shPTEN/shSOCS3-Fibrin	54	Forepaw	Ipsilateral	Mild
31	Untreated	62	Hindpaw	Contralateral	Moderate
30	Untreated	65	Forepaw	Ipsilateral	Moderate
48	Untreated	66	Hindpaw	Ipsilateral	Moderate
41	shPTEN/shSOCS3-Fibrin	72	Hindpaw	Ipsilateral	Mild
42	shPTEN-Fibrin	72	Hindpaw	Ipsilateral	Mild
45	shPTEN/shSOCS3-Fibrin	72	Hindpaw	Ipsilateral	Mild
46	shPTEN/shSOCS3-Fibrin	83	Forepaw	Ipsilateral	Mild

^aLaterality in terms of AAV injection.