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. Author manuscript; available in PMC: 2014 Jul 23.
Published in final edited form as: Nat Commun. 2013;4:2617. doi: 10.1038/ncomms3617

Figure 6. LCK constitutes a potential novel drug target in NSCLC KRASDep cell lines.

Figure 6

(a) LCK knockdown impairs cell proliferation specifically in KRAS-Dep cell lines. LCK knockdown with two independent shRNAs showed statistically significant reduction in cell proliferation in KRAS-Dep but not KRAS-Ind cell lines (LCK shRNA-1 t-test P-value=0.0001822 and LCK shRNA-3 t-test P-value=4.14 exp − 06). Bars correspond to the average of three independent experiments and error bars are defined as s.e.m. (b) Inhibition of LCK using small-molecule inhibitor preferentially impaired cell proliferation in KRAS-Dep but not in KRAS-Ind cell lines. Points represent the average over four independent experiments and error bars are defined as s.e.m.