Table 3.
Percentage of Mature Oocytes With Normal Spindle Integrity in 8 Experimental Groups.a
| Group | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 |
|---|---|---|---|---|---|---|---|---|
| Cyclophosphamide | – | 25 | 50 | 75 | – | 25 | 50 | 75 |
| Imatinib | – | – | – | – | 7.5 | 7.5 | 7.5 | 7.5 |
| Oocytes examined | 32 | 34 | 33 | 31 | 32 | 34 | 30 | 32 |
| Normal metaphase II spindle | 32 | 27 | 26 | 21 | 32 | 33 | 30 | 30 |
| Abnormal metaphase II spindle | 0 | 2 | 5 | 8 | 0 | 0 | 0 | 2 |
| Normal anaphase II spindle | 0 | 5 | 2 | 2 | 0 | 1 | 0 | 0 |
| Percentage of oocytes with normal metaphase II spindle, % | 100 | 79.4 | 78.8 | 67.7 | 100 | 97.1 | 100 | 93.8 |
| P Valueb | – | <.01 | <.01 | <.005 | NS | NS | NS | NS |
| P Valuec | – | – | – | – | – | .054 | <.05 | <.05 |
Abbreviation: NS, not significant.
a Doses indicate mg/kg body weight.
b When compared to untreated controls (group 1) by the chi-square test.
c When compared to imatinib control (ie, between groups 2 and 6, between groups 3 and 7, and between groups 4 and 8) by the chi-square test.