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. 2013 May 5;8(13):1157–1168. doi: 10.3969/j.issn.1673-5374.2013.13.001

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Copyright: © Neural Regeneration Research

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Release of lactate dehydrogenase in hippocampal slices following addition of exogenous interleukin-1α (IL-1α) and interleukin-1β (IL-1β). At 75 minutes following incubation of hippocampal slices in artificial cerebrospinal fluid supplemented with exogenous interleukin-1α (IL-α) or interleukin-1β (IL-β) under normal oxygen conditions, a significant increase in lactate dehydrogenase release was observed. A further increase in lactate dehydrogenase release was observed following the combined addition of IL-1α and IL-1β compared with the addition of IL-1α alone or IL-1β alone. ^aP < 0.01, vs. control group; ^bP < 0.01, vs. IL-1α + IL-1β group. Data are expressed as mean ± SD. Experiments were repeated six times. One-way analysis of variance and least significant difference t-test were used for statistical analysis.