Table 2.
Cytokine levels in lipopolysaccharide (LPS)-stimulated and LPS plus MTEP-stimulated cell cultures
| |
TD |
FXS |
||||
|---|---|---|---|---|---|---|
| Cytokine | LPS | LPS + MTEP | P -value | LPS | LPS + MTEP | P -value |
| GM-CSF |
50.4 (27.9 to 58.9) |
39.8 (36.5 to 49.4) |
0.35 |
45.2 (17.7 to 70.7) |
25.5 (11.7 to 57.6) |
< 0.01b |
| IL-1β |
1,245.3 (957.4 to 1,855.5) |
1,545.9 (972.5 to 2,312.1) |
0.03a |
1,146.0 (607.9 to 1,748.2) |
1,558.4 (883.3 to 2,148.6) |
< 0.01b |
| IL-6 |
3,203.9 (2,043.8 to 4,514.0) |
4,195.3 (2,235.9 to 6,071.8) |
0.12 |
2,900.2 (1,792.2 to 5,110.3) |
3,969.3 (2,352.4 to 7,203.9) |
0.01a |
| IL-10 |
271.2 (106.3 to 765.6) |
415.6 (168.7 to 1,076.6) |
0.03a |
286.8 (184.0 to 573.0) |
389.2 (210.4 to 608.2) |
< 0.01b |
| IL-12(p40) |
59.2 (36.9 to 72.5) |
89.8 (17.3 to 101.8) |
0.53 |
25.0 (6.2 to 77.3) |
43.7 (22.5 to 96.3) |
0.44 |
| TNFα | 838.4 (626.3 to 1,034.4) | 922.5 (531.7 to 1,190.7) | 0.75 | 724.2 (413.0 to 1,381.2) | 925.1 (516.7 to 1,557.1) | 0.93 |
Values reported as median (interquartile range) in pg/mL. All P-values were calculated by Wilcoxon matched-pair signed-rank test. aP < 0.05; bP < 0.01. FXS, fragile X syndrome; MTEP, 3-((2-methyl-1,3-thiazol-4-yl)ethynyl)pyridine hydrochloride; TD, typically developing.