Table 3.
Cytokine levels in phytohemagglutinin (PHA)-stimulated and PHA plus DHPG-stimulated cell cultures
| |
TD |
FXS |
||||
|---|---|---|---|---|---|---|
| Cytokine | PHA | PHA + DHPG | P -value | PHA | PHA + DHPG | P -value |
| GM-CSF |
8.4 (2.3 to 76.9) |
9.6 (4.6 to 45.1) |
0.36 |
11.0 (4.2 to 32.7) |
8.2 (5.2 to 25.8) |
0.81 |
| IFNγ |
9.3 (5.3 to 122.1) |
9.9 (5.1 to 113.0) |
0.72 |
8.6 (3.0 to 113.2) |
5.6 (1.3 to 221.9) |
0.89 |
| IL-10 |
40.3 (17.7 to 144.3) |
34.2 (25.5 to 117.5) |
1.00 |
44.0 (16.5 to 115.0) |
26.9 (15.3 to 74.6) |
< 0.01b |
| IL-13 |
6.2 (3.4 to 135.9) |
7.4 (3.1 to 82.4) |
0.09 |
6.1 (0.2 to 22.1) |
2.6 (0.2 to 18.8) |
< 0.01b |
| IL-17 | 15.4 (6.5 to 70.1) | 15.4 (6.9 to 40.2) | 0.73 | 18.0 (2.7 to 43.6) | 12.1 (5.1 to 34.3) | 0.18 |
Values reported as median (interquartile range) in pg/mL. All P-values were calculated by Wilcoxon matched-pair signed-rank test. bP < 0.01. DHPG, (S)-3,5-dihydroxyphenylglycine; FXS, fragile X syndrome; TD, typically developing.