Table 3.
Diagnostic test for CRP, temperature and SIRS
| Non-bacteremic Patients * n (%) | Bacteremic Patients n (%) | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | + LR (95% CI) | - LR (95% CI) | |
|---|---|---|---|---|---|---|---|---|
| Temperature > 38.0°C |
1879 (88.5) |
245 (11.5) |
64.3 (59.3–69.1) |
80.8 (80.0–81.6) |
11.5 (10.2–13.0) |
98.3 (98.0–98.6) |
3.4 (3.1–3.6) |
0.4 (0.4–0.5) |
| CRP ≥ 100 mg/dL |
2064 (88.2) |
277 (11.8) |
67.4 (62.6–71.9) |
79.0 (78.2–79.8) |
11.8 (10.6–13.2) |
98.3 (98.0–98.6) |
3.2 (3.0–3.5) |
0.4 (0.3–0.5) |
| SIRS |
3546 (92.2) |
301 (7.8) |
72.0 (67.4–76.3) |
69.4 (68.5–70.2) |
7.8 (6.9–8.7) |
98.6 (98.3–98.8) |
2.4 (2.2–2.5) |
0.4 (0.3–0.5) |
| Combination test | 7140 (94.7) | 397 (5.3) | 95.0 (92.4–96.9) | 38.3 (37.4–39.2) | 5.3 (4.8–5.8) | 99.5 (99.3–99-7) | 1.5 (1.5–1.6) | 0.1 (0.1–0.2) |
Results of the diagnostic tests for the clinical parameters temperature, C-reactive protein (CRP), the Systemic Inflammatory Response Syndrome (SIRS) and the Combination test (Temperature >38°C, or a CRP > 100 mg/dL or ≥2 SIRS criteria). Analysed in all adult Medical Emergency Department patients (n = 11,988). PPV: Positive Predictive Value. NPV: Negative Predictive Value. +LR: Positive Likelihood Ratio, −LR: Negative Likelihood Ratio. CI: 95% Confidence Interval.
*: Non blood-cultured and blood cultured non-bacteraemic patients. The percent is presented horizontally.