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Metabolic enzyme scaffold assembly process. (a) Enzymes involved in mavelonate biosynthesis paired with their cognate metazoan scaffolding domain. (b) Individual metabolic enzymes oligomerize and thus create a network of connected scaffold proteins and metabolic enzymes. (c) Basic two-step metabolic pathway shown scaffolded. When metabolic enzymes oligomerize into assembly the intermediate metabolites are concentrated within the assembly while the product freely diffuses away.
