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. 2014 Jul 11;142(4):551–561. doi: 10.1111/imm.12243

Figure 7.

Figure 7

Effect of programmed death 1–immunoglobulin (PD-1-Ig) treatment on B-cell survival in bovine lymphocytes. (a) Percentages of dead cells in CD4+ T cells, CD8+ T cells, and IgM+ B cells among peripheral blood mononuclear cells (PBMCs) treated with bovine IgG or PD-1-Ig (n = 12). (b, c) interferon-γ (IFN-γ) (b) and interleukin-10 (IL-10) (c) productions in IgM+ B-cell-depleted PBMCs were measured by ELISA (n = 10). (d) Proportions of dead cells in PD-L1+ or PD-L1− B cells among PBMCs isolated from cattle were analysed (n = 13). Each line indicates the mean values in each group. Statistical comparisons between bovine IgG and PD-1-Ig were made using the Wilcoxon matched-pairs test. Differences were considered statistically significant at P < 0·05 (*P < 0·05; **P < 0·01).