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. 2014 Jul 11;142(4):581–593. doi: 10.1111/imm.12271

Figure 2.

Figure 2

Rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS) express numerous ligands for natural killer (NK) cell receptors. RA-FLS derived from overgrowth of RA synovial tissue were surface stained for expression of (a) fibroblast-marker CD55 and macrophage-marker CD68 (histograms are representative of n = 3 to n = 5 donors), ligands for activating NK cell receptors (b) NKG2D [MHC class I-chain related protein A,B (MIC-A,B) and UL-16 binding protein 1 (ULBP-1; ULBP-2/5/6,3) and (c) DNAX accessory molecule 1 (DNAM-1; CD155 and CD112), lymphocyte function-associated antigen 1 (LFA-1; CD54) and 2B4/CD244 (CD48); and (d) ligands for inhibitory NK cell receptors. Filled histograms represent isotype-matched control immunoglobulin. Histograms in (b) to (d) are representative of the number of donors indicated in plots of median fluorescence intensity (MFI) beneath.