Table 1.
Effect of ectromelia virus-OVA on mortality rate and survival time of OT-1 mice with c-Jun N-terminal kinase deficiency
| Dose (PFU/mouse)1 | Strain of mice | Total no. of mice | No. of dead mice | Survival time (days) | Mortality (%) | MTD (days)2 |
|---|---|---|---|---|---|---|
| 103 | B6.WT | 10 | 0 | > 21 | 0 | – |
| B6.OT-1 | 10 | 0 | > 21 | 0 | – | |
| JNK1−/−.OT-1 | 10 | 0 | > 21 | 0 | – | |
| JNK2−/−.OT-1 | 10 | 0 | > 21 | 0 | – | |
| 105 | B6.WT | 15 | 1 | 7 | 27 | 9·5 ± 2·5 |
| 2 | 9 | |||||
| 1 | 13 | |||||
| B6.OT-1 | 15 | 0 | > 21 | 0 | – | |
| JNK1−/−.OT-1 | 15 | 1 | 7 | 20 | 8·0 ± 1·0 | |
| 1 | 8 | |||||
| 1 | 9 | |||||
| JNK2−/−.OT-1 | 15 | 2 | 7 | 27 | 8·0 ± 1·4 | |
| 1 | 8 | |||||
| 1 | 10 |
1
Infection route, subcutaneous.
2
MTD, mean time to death. Values represent mean ± SD. Differences in mortality were analysed by chi-square test, and differences in MTD were assessed by Student's t-test.