Table 1.

Summary of non-cancer mammalian pathologies in which MST1/2 kinases are involved

Tissue	Protein	Model	Pathology	References
Liver	MST1/2	MST1/2 mutant conditional mouse	Hepatomegaly	[16,45,46]
Heart	MST1	Mouse model of Arrhythmogenic Cardiomyopathy and human samples	Arrhythmogenic Cardiomyopathy	[47]
		Neonatal rat ventricular myocytes	Heart failure, ischemic heart disease, dilated cardiomyopathy and cardiomyocyte apoptosis	[48-50]
		Dominant negative MST1 mice and MST1 -/- mice	Cardiac dysfunction	[51]
Muscle	MST1	MST1 deficient mice	Neurogenic muscle atrophy	[52]
Brain	MST1	Mouse model of Amyotrophic Lateral Sclerosis	Amyotrophic lateral sclerosis (ALS)	[53]
Pancreas	MST1/2	MST1/2 mutant conditional mouse	Reduction of pancreatic mass, exocrine pancreas disorganization and pancreatitis-like autodigestion	[54,55]
Thymus	MST1	MST1 deficient patients or with homozygous mutations	Immunodeficiency, T and B cells lymphopenia	[21,56]
		MST1 deficient mice	Defective lymphocyte trafficking and thymocyte egress. Autoimmune-like disorders. Impaired development and function of regulatory T cells. Low numbers of mature naïve T cells.	[57-60]
	MST1/2	MST1 and MST2 deficient mice	Autoimmune disease (skin lesions around the eyes, lymphocytes infiltration, colitis)	[17,61]
Lung	MST1/2	MST1/2 mutant conditional mouse	Respiratory distress syndrome	[62]
	MST1	Rat model of Hypoxic pulmonary vascular remodelling	Pulmonary arterial hypertension	[63]