Liver
|
YAP
|
Mouse models of inducible active YAP1 in the liver
|
Increase in liver size
|
[64,65]
|
Heart
|
YAP/TAZ
|
SCA-1-/- human cardiac progenitor cell line
|
Infarct
|
[66]
|
Cardiac-specific YAP or TAZ knockout mice. Mouse model of inducible active YAP1 in the heart
|
Loss of function results in impaired neonatal heart regeneration and lethal cardiomyopathy. Activated YAP enhances cardiac regeneration and improves function of ischemic hearts
|
[67]
|
YAP
|
Mouse models of arrhythmogenic cardiomyopathy and human samples
|
Arrhythmogenic Cardiomyopathy
|
[47]
|
Mouse models of cardiomyocyte-specific homozygous inactivation of YAP in the postnatal heart
|
Increased myocyte apoptosis and fibrosis, dilated cardiomyopathy, and premature death.
|
[68]
|
Muscle
|
YAP
|
Mouse models of inducible active YAP in the skeletal muscle cells
|
Loss of body weight, gait impairments and kyphosis. Skeletal muscle atrophy.
|
[69]
|
Brain
|
YAP/TAZ
|
Rat model of chronic constriction sciatic nerve injury
|
Neuropathic pain
|
[70]
|
YAP/TAZ
|
Mammalian cell lines
|
Alzheimer’s disease
|
[71]
|
Pancreas
|
YAP
|
MST1/2 mutant conditional mouse
|
Reduction of pancreatic mass, exocrine pancreas disorganization and pancreatitis-like autodigestion
|
[54,55]
|
Mouse models of inducible active YAP1 in the pancreas
|
Pancreas increased in total size and acinar cells showed penetrant ductal metaplasia
|
[64]
|
Skin
|
YAP/TAZ
|
Mice model of wound healing
|
Wound healing
|
[72]
|
YAP
|
Mouse models of inducible active YAP1 in the skin
|
Thickening of the epidermis and increased number of proliferating cells
|
[64]
|
Eye
|
YAP/TAZ
|
Primary human trabecular meshwork cells
|
Glaucoma
|
[73]
|
Ovary |
YAP/TAZ |
Mouse model of ovarian fragmentation, ovarian explant and follicle cultures. Primary ovarian insufficiency patients |
Primary ovarian insufficiency and polycystic ovarian syndrome |
[74] |