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. 2014 Jul 23;6:162. doi: 10.3389/fnagi.2014.00162

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Copyright © 2014 Patel, Grizzell, Holmes, Zeitlin, Solomon, Sutton, Rohani, Charry, Iarkov, Mori and Echeverria Moran.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cotinine prevented cognitive impairment in Tg6799 mice. 4.5–5 month-old mice (n = 8 per group) were treated daily for 3 months and tested in the radial arm water maze (RAWM; A). Chronic cotinine treatment (5 mg/kg) diminished cognitive impairment in the transgenic (Tg) mice as assessed using the RAWM testing for working memory. This tests revealed that cotinine-treated Tg mice (Tg + Cot 5) made fewer errors than vehicle-treated Tg mice (Tg + Veh) when tested overall (^**p < 0.01; B) and during the final block of testing (^**p < 0.01; D). Latencies between groups overall (C) and during the final block (E) are also shown. Tx, treatment; WB, Western blot.