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. 2014 Jul 10;15:28. doi: 10.1186/1471-2121-15-28

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Copyright © 2014 Wimuttisuk et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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LRR5 regulates FAZF abundance. A. LRR5 was co-expressed with either PLZF (lane 2) or FAZF (lane 4). Binding was only seen with the LRR5/FAZF pair (upper blot, lane 4). Protein levels are shown in lower two blots. B. Coexpression of LRR5 and FAZF results in reduced FAZF expression (upper blot, lane 1 vs lane 2). Levels of FAZF are restored during co-expression when the proteasome is inhibited by MG-132 (lanes 3 and 4). Relative protein levels are shown in lower blots. C. LRR5 expression reduces levels of endogenous FAZF, upper blot shows LRR5 expression with increasing amounts of shRNA. Middle blot is endogenous FAZF (arrow). Lower blot is actin to show relative protein loading levels. D. Same as in C, but instead of co-expression LRR5, LRR1 was used.