Table 3. Mean changes in plasma lipoprotein cholesterol and triglycerides by follow-up pregnancy and birth groups of Black women nulliparous at baseline, the Coronary Artery Risk Development in Young Adults Study, 1985–1996.
| Lipid profile | Time-dependent follow-up pregnancy and birth group | ||||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| P0: no pregnancies (referent) (n = 224) |
P1: one or more short
pregnancies (n = 65) |
B1: one birth (n = 135) |
B2: two or more births (n = 82) |
Global p value | |||||
|
|
|
|
|
||||||
| Mean | 95% CI† | Mean | 95% CI | Mean | 95% CI | Mean | 95% CI | ||
| ΔTotal cholesterol (mg/dl) | |||||||||
| Minimally adjusted‡ | −7.1 | − 9.7, −4.5 | −2.3 | −7.4, 2.8 | −5.0 | −8.2, −1.8 | −7.7 | −12.6, −2.8 | 0.28 |
| Fully adjusted§ | −6.4 | − 9.0, −3.8 | −1.4 | − 6.6, 3.8 | −6.5 | −9.8, −3.2 | −9.3 | −14.4, −4.2 | 0.17 |
| ΔHDL† cholesterol (mg/dl) | |||||||||
| Minimally adjusted | 0.5 | − 0.7, 1.6 | −3.2** | −5.4, −1.0 | −3.3*** | −4.7, −1.9 | −4.9*** | −7.0, −2.8 | <0.001 |
| Fully adjusted | −0.1 | − 1.1, 1.0 | −2.4 | −4.5, −0.3 | −2.9*** | −4.2, −1.6 | −4.1*** | −6.2, −2.1 | 0.003 |
| ΔLDL† cholesterol (mg/dl) | |||||||||
| Minimally adjusted | −8.1 | − 10.5, −5.8 | −1.6* | −6.2, 3.1 | −3.8* | −6.8, −0.9 | −5.4 | −9.8, −0.9 | 0.04 |
| Fully adjusted | −7.1 | − 9.4, −4.7 | − 1.3 | − 6.0, −3.3 | −5.4 | −8.4, −2.5 | −7.4 | −12.0, −2.8 | 0.14 |
| ΔTriglycerides (mg/dl) | |||||||||
| Minimally adjusted | 0.8 | − 2.4, 4.0 | 9.8* | 3.2, 16.3 | 7.7** | 3.7, 11.8 | 10.4* | 4.1, 16.7 | 0.02 |
| Fully adjusted | 2.2 | − 0.9, 5.2 | 8.7 | 2.2, 15.1 | 6.1 | 2.0, 10.1 | 9.0 | 2.7, 15.3 | 0.17 |
*
p < 0.05;
**
p < 0.01;
***
p < 0.001; pairwise comparisons to referent group.
†
CI, confidence interval; HDL, high density lipoprotein; LDL, low density lipoprotein.
‡
Minimally adjusted models included study center, time, baseline characteristics (body weight, height, waist circumference, education, smoking status, dieting to lose weight, oral contraceptive use, dietary carbohydrates and saturated fat, alcohol intake, and physical activity score), and time-dependent age and number of short pregnancies.
§
Fully adjusted models additionally included time-dependent covariates (smoking status, months of oral contraceptive use, education, and changes in body weight, waist circumference, physical activity score, and alcohol intake).