Table 4.
Within subject (daily) variation in 45 acylcarnitines – nearest neighbor ratios
| ||||
|---|---|---|---|---|
| Individual Acylcarnitine | ||||
| 1. Acetyl carnitine, C2 | 1.21 ** | 1.02 | 1.06 | 0.98 |
| 2. Propionyl carnitine, C3 | 1.23 ** | 1.14 * | 1.31** | 0.99 |
| 3. Butyryl/Isobutyryl carnitine, C4/Ci4 | 1.08 | 0.85 | 1.08 | 0.95 |
| 4. Tiglyl carnitine, C5:1 | 1.15 | 1.10 | 0.94 | 0.94 |
| 5. Isovaleryl/3-Methylebutyryl/2-Methylbutyryl carnitine, C5’s | 0.97 | 1.08 | 1.30* | 1.05 |
| 6. β-hydroxy butyryl carnitine, C4OH | 0.97 | 1.33 * | 1.04 | 1.49 |
| 7. Hexanoyl carnitine, C6 | 1.48 * | 1.00 | 1.01 | 1.02 |
| 8. 3-Hydroxy-isovaleryl/Malonyl carnitine, C5OH/C3DC | 0.98 | 0.88 | 1.17 | 0.89 |
| 9. Methylmalonyl/ Succinyl carnitine, Ci4DC/C4DC | 1.05 | 1.13 | 1.10 | 1.03 |
| 10. Octenoyl carnitine, C8:1 | 1.17 *** | 0.86 ** | 1.01 | 0.97 |
| 11. Octanoyl carnitine, C8 | 2.16 *** | 0.61 *** | 0.75** | 0.63 |
| 12. Glutaryl carnitine, C5DC | 1.07 | 1.06 | 0.87 | 0.92 |
| 13. Adipoyl carnitine, C6DC | 1.19 *** | 0.86 | 1.03 | 0.82 |
| 14. Decatrienoyl carnitine, C10:3 | 1.15 *** | 0.95 | 1.08** | 0.97 |
| 15. Decadienoyl carnitine, C10:2 | 1.23 *** | 0.98 | 1.14 | 0.74 |
| 16. Decenoyl carnitine, C10:1 | 2.20 *** | 0.57*** | 0.85 | 0.84 |
| 17. Decanoyl carnitine, C10 | 2.34 *** | 0.51*** | 0.71** | 0.65** |
| 18. 3-Hydroxy-decanoyl/ Suberoyl carnitine, C10-OH/C8-DC | 1.53 *** | 0.75 | 0.96 | 0.78 |
| 19. Dodecenoyl carnitine, C12:1 | 1.94 *** | 0.62*** | 0.90 | 0.63** |
| 20. Lauroyl carnitine, C12 | 2.07 *** | 0.78** | 0.91 | 0.73** |
| 21. 3-Hydroxy-dodecanoyl/ Sebacoyl carnitine, C12-OH/ C10-DC | 1.71 ** | 0.86 | 0.88 | 0.69 |
| 22. Tetradecadienoyl carnitine, C14:2 (μM) | 2.19 *** | 0.62*** | 0.67** | 0.93 |
| 23. Tetradecenoyl carnitine, C14:1 | 1.74 *** | 0.71*** | 0.79 | 0.86 |
| 24. Myristoyl carnitine, C14 | 1.59 *** | 0.81* | 0.86 | 0.85 |
| 25. 3-Hydroxy-tetradecenoyl carnitine, C14:1-OH | 1.40 *** | 0.89 | 1.00 | 0.80 |
| 26. 3-Hydroxy-tetradecanoyl/ Dodecanedioyl carnitine, C14-OH/C12-DC | 1.40 ** | 0.87 | 0.83 | 0.89 |
| 27. Palmitoyl carnitine, C16 | 1.19 *** | 0.97 | 0.90 | 0.96 |
| 28. 3-Hydroxy-hexadecanoyl/ Tetradecanedioyl carnitine, C16-OH/C14-DC | 1.23 * | 1.17 | 0.96 | 0.90 |
| 29. Linoleyl carnitine, C18:2 | 1.24 *** | 0.75** | 0.82 | 1.25 |
| 30. Oleyl carnitine, C18:1 | 1.15 ** | 0.91* | 0.90 | 1.03 |
| 31. Stearoyl carnitine, C18 | 1.07 | 0.95 | 0.89 | 1.01 |
| 32. 3-Hydroxy-octadecenoyl carnitine, C18:1-OH | 1.36 * | 0.88 | 0.83 | 0.91 |
| 33. 3-Hydroxy-octadecanoyl/ Hexadecanedioyl carnitine, C18-OH/C16-DC | 1.13 | 1.04 | 1.15 | 0.82 |
| 34. Arachidoyl carnitine, C20 | 1.40 * | 0.90 | 1.15 | 0.93 |
| 35. Octadecenedioyl carnitine, C18:1-DC | 1.48 *** | 0.84 | 1.04 | 1.00 |
| 36. 3-Hydroxy-eicosanoyl/Octadecanedioyl carnitine, C20-OH/C18-DC | 1.43 *** | 0.91 | 1.14 | 0.91 |
| 37. Docosanoyl carnitine, C22 | 1.15 | 0.79 | 1.26 | 1.12 |
| 38. 3-Hydroxy-cis-5-octenoyl/ Hexenedioyl carnitine, C8:1-OH/C6:1-DC | 1.32 ** | 0.97 | 1.18* | 0.85 |
| 39. Heptanedioyl carnitine, C7-DC | 1.00 | 1.00 | 2.69** | 0.68 |
| 40. Octenedioyl carnitine, C8:1-DC | 1.42 *** | 0.80 | 0.96 | 0.75* |
| 41. Hexadecadienoyl carnitine, C16:2 | 1.42 * | 0.68 | 0.77 | 1.07 |
| 42. Palmitoleoyl carnitine, C16:1 | 1.46 *** | 0.81*** | 0.72 | 0.97 |
| 43. 3-Hydroxy-palmitoleoyl/ cis-5-Tetradecenedioyl carnitine, C16:1-OH/C14:1-DC, | 1.25 | 1.08 | 1.16 | 0.88 |
| 44. 3-Hydroxy-linoleyl carnitine, C18:2-OH | 1.06 | 0.97 | 0.97 | 0.95 |
| 45. Arachidonoyl carnitine, C20:4 | 1.12 * | 0.99 | 1.33 | 1.14 |
For each subject, the ratio of each time point relative to its previous time point was calculated using log-transformed (ln) values. Median values of the individual ratios are presented and P values (where the null hypothesis is that the overall ratio = zero) were generated by the Signed Rank Statistic. P values:
*
p<0.05,
**
p<0.01,
***
p<0.001.