Figure 2.

Structural organization of the MRX/N complex. (A) Schematic showing domains of the Mre11, Rad50, and Nbs1/Xrs2 proteins. Interaction domains are shown as color-coded circles, and other functional domains are indicated by rectangles. LL, latching loop; CD, capping domain; DBD, DNA-binding domain; FHA, forkhead associated; BRCT, BRCA1 carboxy-terminal domain. (B) Panel created from data in Lim et al. (2011) to show how ATP hydrolysis by Rad50 causes a conformational change exposing the Mre11 active site. Note that there are no structures of the entire MRX/N complex, or the complex with Sae2/Ctp1/CtIP, and the cartoon depicts the known interactions based on partial complexes.